|
KMID : 1037120190370020148
|
|
The World Journal of Men′s Health
2019 Volume.37 No. 2 p.148 ~ p.156
|
|
|
Epigenetics of Male Fertility: Effects on Assisted Reproductive Techniques
|
|
Giacone Filippo
Cannarella Rossella
Mongioi Laura M.
Alamo Angela
Condorelli Rosita A.
Calogero Aldo E.
La Vignera Sandro
|
|
|
Abstract
|
|
|
|
During the last decades the study of male infertility and the introduction of the assisted reproductive techniques (ARTs) has allowed to understand that normal sperm parameters do not always predict fertilization. Sperm genetic components could play an important role in the early stages of embryonic development. Based on these acquisitions, several epigenetic investigations have been developed on spermatozoa, with the aim of understanding the multifactorial etiology of male infertility and of showing whether embryonic development may be influenced by sperm epigenetic abnormalities. This article reviews the possible epigenetic modifications of spermatozoa and their effects on male fertility, embryonic development and ART outcome. It focuses mainly on sperm DNA methylation, chromatin remodeling, histone modifications and RNAs.
|
|
|
KEYWORD
|
|
|
Epigenomics, Infertility, Infertility, male, Reproductive techniques, assisted
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
   
|